Post-doctoral Research Fellow Job Opportunity: NMGN Congenital Anomalies

We have a 3 year funded MRC-funded postdoctoral position available in Mill lab (MRC Human Genetics Unit, University of Edinburgh), as part of the Congenital Anomalies Cluster for the MRC National Mouse Genetics Network (NMGN). The candidate will be part of a cohort of 5 postdocs from Newcastle, KCL, UCL, and Oxford universities working towards developing new mouse models of human disease and technologies to help us understand how changes in our genomes, also called variants, can cause the severe anatomical malformations found in approximately 1 in 20 births. Each year this equates to 8 million affected newborns, of which 300,000 die within the first four weeks of life. With recent advances in sequencing technology, we are accelerating the identification of possible disease-causing changes in the genetic code of these patients. However, it is a major challenge to prove which of these variants do cause these malformations, as well as to establish the cellular mechanisms by which these changes disrupt normal development.

We are looking for a talented, curious and collaborative colleague who is excited about using cutting-edge technologies to join our team to develop pre-clinical models of human ciliopathies. Their project will investigate molecular mechanisms underlying disease progression, deep phenotyping across neonatal periods and establish key molecular and cellular phenotypes of disease. The post will work towards understanding reversibility of these ciliopathic disease phenotypes in different tissue settings in our pre-clinical mouse models. The post will involve liaising within the Mill team at the HGU, as well as nationally with partners across the UK, at the Mary Lyon Centre (Harwell) and Nucleic Acid Therapy Accelerator (NATA: Harwell).

Who are we looking for? Someone with:

• PhD or equivalent degree (MD/PHD etc) in Genetics, Molecular Biology, Genomics, Biology or related fields.

• Strong communication skills.

• Expertise in genomics, bioinformatics (especially proteomics, RNAseq analysis), developmental biology, and/or cell biology is preferred, but not necessary.

• Experience with model organisms is preferred.

• Experience in advanced imaging and image analysis is preferred.

Peaked your interest? The full job advert can be found here: https://elxw.fa.em3.oraclecloud.com/hcmUI/CandidateExperience/en/sites/CX_1001/job/7216

We encourage informal enquiries to discuss more by emailing Pleasantine.