Cilia loss, changes in actin cytoskeleton and microenvironment lead to polycystic disease!

A busy pre-print week for us- but we are thrilled to share Scott’s thesis work fom my lab and Boulter lab on unifying how cilia loss (or defects in cilia-localized signaling) converge on polycystic disease, common mechanisms and signatures induced to rewire cystic microenvironment, as as well as super cool lineage tracing of cyst progenitors in polycystic livers! For a deep read: https://www.biorxiv.org/content/10.1101/2022.04.08.487546v1.full.pdf